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News/Do Perturbation Predictors Learn Gene Interactions? Diagnosing Extrapolation in Agentic Screening
arxiv
PublishedOctober 15, 2026 at 4:00 AM

Do Perturbation Predictors Learn Gene Interactions? Diagnosing Extrapolation in Agentic Screening

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arXiv:2610.18880v1 Announce Type: new Abstract: High-throughput perturbation screens increasingly use machine-learning models to predict the effects of gene combinations that were never measured. A difficult case arises when both genes in a test pair were seen individually during training, but their

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