15 articles mentioning POCKET-Darwin-180B-GGUF
arXiv:2610.17696v1 Announce Type: cross Abstract: Identifying protein-ligand binding sites (pockets) is important for understanding protein function and developing drugs. However, no public method has leveraged co-folding models for novel pocket prediction; furthermore, this task lacks a suitable be
arXiv:2610.00988v1 Announce Type: new Abstract: Cryptic ligand-binding pockets are not apparent in experimentally determined apo structures, making them difficult to identify from unbound receptor geometry. A complementary challenge is to make the structural measurements and learned evidence behind
arXiv:2609.31222v1 Announce Type: new Abstract: Pocket-conditioned molecular diffusion updates ambient atom coordinates, but many lead-optimization objectives are expressed on quotient features such as distances, contacts, and anchored substructures. We introduce budgeted quotient-residual guidance
arXiv:2609.31135v1 Announce Type: cross Abstract: Spatio-Temporal Video Grounding (STVG) aims to localize the spatio-temporal tube in a video corresponding to a natural language query. While recent methods achieve strong performance in fully supervised, weakly supervised, and zero-shot settings, the
Pocket FM uses AI to produce 99% of its new content, helping make content production about 80 times cheaper.
arXiv:2609.05097v1 Announce Type: cross Abstract: AI-driven de novo molecular design offers a promising route to accelerate early-stage drug discovery by generating novel ligands directly within target protein binding pockets. We present NEAT-POCKET, a pocket-conditioned extension of the autoregress
arXiv:2609.02963v1 Announce Type: cross Abstract: Lead optimization in structure-based drug design aims to improve target binding while avoiding unintended interactions with off-target pockets. However, existing affinity-driven methods do not explicitly control specificity, whereas current specifici
arXiv:2607.12349v1 Announce Type: new Abstract: Drug discovery and development is time-consuming and resource-intensive, motivating computational approaches such as diffusion models for de novo drug design. Many such models follow the structure-based drug design (SBDD) paradigm, generating molecules
Meta has quietly launched Pocket, an experimental AI app that lets users generate and share interactive mini games using text prompts.
arXiv:2606.04020v1 Announce Type: cross Abstract: Splice-mediated drug resistance occurs in up to 40% of patients on targeted kinase inhibitors, yet state-of-the-art druggability tools operate on single structures and cannot compare across isoforms. We introduce SpliceBind, a graph neural network fr
arXiv:2606.03948v1 Announce Type: new Abstract: We implement simultaneous translation capability with the offline direct speech-to-text translation model Canary, using the state-of-the-art policy AlignAtt, and submit it to IWSLT 2026 Simultaneous Speech Translation Shared task for Czech to English a
arXiv:2605.29299v2 Announce Type: replace-cross Abstract: Evaluations of dental vision-language models remain fragmented across datasets, task definitions and metrics, and often ignore their computational cost. This limits their widespread deployment for dental screening outside specialist centres,
arXiv:2605.17693v1 Announce Type: cross Abstract: Structure-based drug design has been accelerated by pocket-aware 3D generative models, yet most methods primarily fit the training distribution and may fall short of satisfying multiple properties required in real-world therapeutic drug discovery. Re
arXiv:2605.18654v1 Announce Type: cross Abstract: A fraud scorer needs to answer in under 2 ms. The best tabular foundation models (TFMs) take 151-1,275 ms on GPU. We close this gap by distilling the TFM offline into an XGBoost or CatBoost student that runs natively on CPU. The central obstacle is s
arXiv:2604.23134v1 Announce Type: new Abstract: Accurate molecular representations are critical for drug discovery, and a central challenge lies in capturing the chemical environment of molecular fragments, as key interactions, such as H-bond and {\pi} stacking, occur only under specific local condi